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Article

Rewiring the keyboard: evolvability of the genetic code.

Nature reviews. Genetics - 1 Jan 2001

Knight R D, Freeland S J, Landweber L F

Abstract excerpt

The genetic code evolved in two distinct phases. First, the 'canonical' code emerged before the last universal ancestor; subsequently, this code diverged in numerous nuclear and organelle lineages. Here, we examine the distribution and causes of these secondary deviations from the canonical genetic code. The majority of non-standard codes arise from alterations in the tRNA, with most occurring by...

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Identifiers

PMID: 11253070
DOI: 10.1038/35047500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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