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Article

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness.

Nature - 11 Mar 2010

Meer Margarita V, Kondrashov Alexey S, Artzy-Randrup Yael, Kondrashov Fyodor A

Abstract excerpt

A long-standing controversy in evolutionary biology is whether or not evolving lineages can cross valleys on the fitness landscape that correspond to low-fitness genotypes, which can eventually enable them to reach isolated fitness peaks. Here we study the fitness landscapes traversed by switches between different AU and GC Watson-Crick nucleotide pairs at complementary sites of mitochondrial transfer RNA stem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20182427
DOI: 10.1038/nature08691

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