Article
Transfer RNA genes experience exceptionally elevated mutation rates.
Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2018
Thornlow Bryan P, Hough Josh, Roger Jacquelyn M, Gong Henry, Lowe Todd M, Corbett-Detig Russell B
Abstract excerpt
Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things. Despite their clear significance for fundamental cellular processes, the forces governing tRNA evolution are poorly understood. We present evidence that transcription-associated mutagenesis and strong purifying selection are key...
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