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Article

Mutation accumulation in transfer RNAs: molecular evidence for Muller's ratchet in mitochondrial genomes.

Molecular biology and evolution - 1 Jan 1996

Lynch M

Abstract excerpt

The accumulation of deleterious mutations is thought to be a major factor preventing the long-term persistence of obligately asexual lineages relative to their sexual ancestors. This phenomenon is also of potential relevance to sexual species that harbor asexually propagating organelle genomes. A comparative study of the transfer RNA genes in animal mitochondrial and nuclear genomes demonstrates that the former...

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PMID: 8583893
DOI: 10.1093/oxfordjournals.molbev.a025557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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