Article
Precancerous niche remodelling dictates nascent tumour persistence.
Nature - 1 May 2026
Skrupskelyte G, Rojo Arias J E, Ajith H, Dang Y, Rossetti D, Han S, Tang M K S, Bejar M T, Colom B, Fowler J C, Murai K, Knight W, Aust D, Schmidt M H H, Jászai J, Zeki S, Noorani A, Jones P H, Rulands S, Simons B D, Alcolea M P
Abstract excerpt
Interactions between mutant cells and their environment have a key role in determining cancer susceptibility1-3. However, understanding of how the precancerous microenvironment contributes to early tumorigenesis remains limited. Here we show that newly emerging tumours at their most incipient stages shape their microenvironment in a critical process that determines their survival. Analysis of nascent squamous...
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