Precancerous niches as gatekeepers of tumor initiation.

Abstract excerpt

Clonal competition eliminates most early neoplastic lesions, yet a subset persists and ultimately progresses. In Nature, Skrupskelyte et al. demonstrate that nascent tumors survive by actively reshaping a precancerous niche through epithelial-stromal feedback. This ecological gatekeeping mechanism reframes tumor initiation from a process of mutation accumulation to microenvironmental selection and co-evolution.

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