Article
Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage.
Cancer discovery - 3 Jun 2025
Li Yun Rose, Kandyba Eve, Halliwill Kyle, Delrosario Reyno, Tran Quan, Bayani Nora, Wu Di, Mirzoeva Olga K, Reeves Melissa Quino, Islam S M Ashiqul, Riva Laura, Bergstrom Erik N, Achanta Kavya, DiGiovanni John, Alexandrov Ludmil B, Balmain Allan
Abstract excerpt
Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. In this study, we carried out whole-genome sequencing to demonstrate that...
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