Article
Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancer
2023-10-12
Abstract excerpt
Long-lived species suppress cancer despite accumulating somatic mutations throughout life, but how this is achieved in renewing tissues remains unclear. Here, we show that naked mole-rat skin uncouples high cellular turnover from cancer risk through coordinated epithelial and stromal mechanisms that constrain clonal outgrowth and suppress tumor-promoting inflammation. Despite elevated epidermal proliferation and m...
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Identifiers and source
- Literature Corpus work
- 23751506-c5a6-53af-97fd-732ccecfde9f
- DOI
- 10.1101/2023.10.10.561212