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Article

Pharmacogenetics of CYP3A5 in Pediatric Patients With Eosinophilic Esophagitis.

Clinical and translational science - 1 Mar 2026

Noel-MacDonnell Janelle, Almahbub Norah, Boone Erin, Wang Wendy, Cheranova Dilyara, Harvey Lisa, Shakhnovich Valentina, Chevalier Rachel

Abstract excerpt

Eosinophilic esophagitis (EoE) is an atopic inflammatory disease with limited treatment options. Though swallowed topical steroids are commonly used, they are not effective in all patients. We investigated the presence of CYP3A4/5 and ABCB1 (P-glycoprotein) mRNA in esophageal tissue and its differential expression by genotype in pediatric patients. Esophageal tissue biopsies were obtained from pediatric patients...

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Source

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Identifiers

PMID: 41772361
DOI: 10.1111/cts.70516
PMCID: PMC12953044

Genes

CYP3A5
ABCB1
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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