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Article

Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia.

Neurogastroenterology and motility - 1 Jan 2022

Yasuda Jessica L, Staffa Steven J, Nurko Samuel, Kane Madeline, Wall Stephanie, Mougey Edward B, Franciosi James P, Manfredi Michael A, Rosen Rachel

Abstract excerpt

BACKGROUND: Esophagitis is prevalent in patients with esophageal dysmotility despite acid suppression, likely related to poor esophageal clearance. Esophageal atresia (EA) is a classic model of dysmotility where this observation holds true. In adult non-dysmotility populations, failure of esophagitis to respond to proton pump inhibitors (PPI) has been linked to variants in CYP2C19 that influence the activity of...

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Identifiers

PMID: 34337835
DOI: 10.1111/nmo.14217
PMCID: PMC10302247

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