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Article

Variability in Expression of CYP3A5 in Human Fetal Liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2015

Vyhlidal Carrie A, Pearce Robin E, Gaedigk Roger, Calamia Justina C, Shuster Diana L, Thummel Kenneth E, Leeder J Steven

Abstract excerpt

Members of the cytochrome P450 3A (CYP3A) subfamily of drug metabolizing enzymes exhibit developmental changes in expression in human liver characterized by a transition between CYP3A7 and CYP3A4 over the first few years of life. In contrast, the developmental expression of CYP3A5 is less well un...

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Share to Biotransformation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxylation

Share to Microsomes, Liver

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Source

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Identifiers

PMID: 25979262
DOI: 10.1124/dmd.115.064998
PMCID: PMC6067386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25979262-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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