Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes.

doi:10.3390/ijms25126548

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Article

Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes.

International journal of molecular sciences - 14 Jun 2024

Nkoy Flory L, Stone Bryan L, Deering-Rice Cassandra E, Zhu Angela, Lamb John G, Rower Joseph E, Reilly Christopher A

Abstract excerpt

Genetic variation among inhaled corticosteroid (ICS)-metabolizing enzymes may affect asthma control, but evidence is limited. This study tested the hypothesis that single-nucleotide polymorphisms (SNPs) in Cytochrome P450 3A5 (CYP3A5) would affect asthma outcomes. Patients aged 2-18 years with persistent asthma were recruited to use the electronic AsthmaTracker (e-AT), a self-monitoring tool that records weekly...

Topics

Humans
Asthma
Child
Male
Female
Polymorphism, Single Nucleotide
Cytochrome P-450 CYP3A
Adolescent
Child, Preschool
Adrenal Cortex Hormones
Genotype
Hydrocortisone
Saliva
Treatment Outcome

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Identifiers

PMID: 38928254
DOI: 10.3390/ijms25126548
PMCID: PMC11203737

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