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Article

Functional polymorphisms in CYP2C19 & CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis.

The Indian journal of medical research - 1 May 2012

Feng Wei-Xing, Liu Fang, Gu Yi, Jiao Wei-Wei, Sun Lin, Xiao Jing, Wu Xi-Rong, Miao Qing, Shen Chen, Shen Dan, Shen Adong

Abstract excerpt

BACKGROUND & OBJECTIVES: Tuberculosis (TB) bacilli ingested by macrophages evade host immune responses by multiple mechanisms including the inhibition of apoptosis. As the cytochrome-P-450 system (CYP) contributes to apoptosis it has been suggested that genetic variation in CYP may be associated with susceptibility to TB infection. This study was carried out to evaluate cytochrome P-450 polymorphisms in Chinese...

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Identifiers

PMID: 22771593
PMCID: PMC3401694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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