Common variants at 5q22 associate with pediatric eosinophilic esophagitis.

doi:10.1038/ng.547

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Article

Common variants at 5q22 associate with pediatric eosinophilic esophagitis.

Nature genetics - 1 Apr 2010

Rothenberg Marc E, Spergel Jonathan M, Sherrill Joseph D, Annaiah Kiran, Martin Lisa J, Cianferoni Antonella, Gober Laura, Kim Cecilia, Glessner Joseph, Frackelton Edward, Thomas Kelly, Blanchard Carine, Liacouras Chris, Verma Ritu, Aceves Seema, Collins Margaret H, Brown-Whitehorn Terri, Putnam Phil E, Franciosi James P, Chiavacci Rosetta M, Grant Struan F A, Abonia J Pablo, Sleiman Patrick M A, Hakonarson Hakon

Abstract excerpt

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9)). TSLP is overexpressed in esophageal biopsies...

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PMID: 20208534
DOI: 10.1038/ng.547
PMCID: PMC3740732

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TSLP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20208534-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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