The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells.

doi:10.1124/dmd.124.001684

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells.

Drug metabolism and disposition: the biological fate of chemicals - 16 Jul 2024

Almestica-Roberts Marysol, Nguyen Nam D, Sun Lili, Serna Samantha N, Rapp Emmanuel, Burrell-Gerbers Katherine L, Memon Tosifa A, Stone Bryan L, Nkoy Flory L, Lamb John G, Deering-Rice Cassandra E, Rower Joseph E, Reilly Christopher A

Abstract excerpt

This study investigated an association between the cytochrome P450 (CYP) 2C8*3 polymorphism with asthma symptom control in children and changes in lipid metabolism and pro-inflammatory signaling by human bronchial epithelial cells (HBECs) treated with cigarette smoke condensate (CSC). CYP genes are inherently variable in sequence, and while such variations are known to produce clinically relevant effects on drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchi

Share to Cyclopropanes

Share to Cytochrome P-450 CYP2C8

Share to Epithelial Cells

Share to Lipid Metabolism

Share to Quinolines

Share to Sulfides

Source

Open in PubMed Open full text

Identifiers

PMID: 38772712
DOI: 10.1124/dmd.124.001684
PMCID: PMC11257687

Genes

CYP2C8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells.PMID 38772712Read ↗

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesSemantic proximity Read ↗

Updated analysis of the pharmacogenomics of pediatric bronchodilator response.Semantic proximity Read ↗

Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukastSemantic proximity Read ↗

Pharmacogenetics of Bronchodilator Response: Future Directions.Semantic proximity Read ↗

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.Semantic proximity Read ↗

A transcriptomic approach to elucidate the physiological significance of human cytochrome P450 2S1 in bronchial epithelial cells.Semantic proximity Read ↗

Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes.Semantic proximity Read ↗

Transcriptomic and Functional Responses of Human Airway Cells to Vaped ∆8-THC and its Oxidation Product ∆8-THCQSemantic proximity Read ↗

Exploring the roles of UGT1A1 and UGT1A3 in oral clearance of GSK2190915, a 5-lipoxygenase-activating protein inhibitor.Semantic proximity Read ↗

CYP2J2 - regulation, function and polymorphism.Semantic proximity Read ↗

Xenobiotic metabolism in differentiated human bronchial epithelial cellsSemantic proximity Read ↗

Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma ControlSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.