Article
The Absence of CYP3A5*3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects.
PloS one - 1 Jan 2015
Tanno Luciana Kase, Kerr Daniel Shikanai, dos Santos Bernardo, Talib Leda Leme, Yamaguti Célia, Rodrigues Helcio, Gattaz Wagner Farid, Kalil Jorge
Abstract excerpt
Although aromatic anticonvulsants are usually well tolerated, they can cause cutaneous adverse drug reactions in up to 10% of patients. The clinical manifestations of the antiepileptics-induced hypersensitivity reactions (AHR) vary from mild skin rashes to severe cutaneous drug adverse reactions which are related to high mortality and significant morbidity. Genetic polymorphisms in cytochrome P450 genes are...
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