Article
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.
Nature genetics - 1 Oct 2023
Chen Yanhua, Du Xiaomeng, Kuppa Annapurna, Feitosa Mary F, Bielak Lawrence F, O'Connell Jeffrey R, Musani Solomon K, Guo Xiuqing, Kahali Bratati, Chen Vincent L, Smith Albert V, Ryan Kathleen A, Eirksdottir Gudny, Allison Matthew A, Bowden Donald W, Budoff Matthew J, Carr John Jeffrey, Chen Yii-Der I, Taylor Kent D, Oliveri Antonino, Correa Adolfo, Crudup Breland F, Kardia Sharon L R, Mosley Thomas H, Norris Jill M, Terry James G, Rotter Jerome I, Wagenknecht Lynne E, Halligan Brian D, Young Kendra A, Hokanson John E, Washko George R, Gudnason Vilmundur, Province Michael A, Peyser Patricia A, Palmer Nicholette D, Speliotes Elizabeth K
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective treatments. We carried out a genome-wide association study (GWAS) meta-analysis of imaging (n = 66,814) and diagnostic code (3,584 cases versus 621,081 controls) measured NAFLD across diverse ancestries. We identified NAFLD-associated variants at torsin family 1 member B (TOR1B), fat mass and obesity associated (FTO),...
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