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Article

Effect of p53 gene mutation with loss of function on the expression of genes and proteins involved in cell proliferation.

Mutation research - 1 Jan 2026

Kim Gyeong Hee, Kim Moon-Moo

Abstract excerpt

The tumor suppressor gene TP53 plays a vital role in preserving genomic integrity by regulating cell cycle progression, DNA repair mechanisms, and apoptosis. This study aims to examine how CRISPR/Cas9-induced loss-of-function mutations in the p53 gene influence cellular processes on cell cycle regulation and tumorigenic signaling in HT1080 human fibrosarcoma cells. Successful TP53 gene disruption was confirmed by...

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Share to Cell Cycle
Share to Cell Line, Tumor
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Gene Expression Regulation, Neoplastic

Share to Loss of Function Mutation

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41734599
DOI: 10.1016/j.mrfmmm.2026.111931

Genes

TP53
BAX
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Effect of p53 gene mutation with loss of function on the expression of genes and proteins involved in cell proliferation.PMID 41734599Read ↗

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