Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural biology of the tumor suppressor p53 and cancer-associated mutants.

Advances in cancer research - 1 Jan 2007

Joerger Andreas C, Fersht Alan R

Abstract excerpt

The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. In response to oncogenic or other stresses, the p53 protein is activated and regulates the expression of a variety of target genes, resulting in cell cycle arrest, senescence, or apoptosis. Mutation of the p53 gene is the most common genetic alteration in human cancer, affecting more than 50%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to DNA, Neoplasm
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Design

Share to Genes, p53

Share to Protein Denaturation

Share to Structure-Activity Relationship

Share to Suppression, Genetic

Source

Identifiers

PMID: 17419939
DOI: 10.1016/S0065-230X(06)97001-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural biology of the tumor suppressor p53 and cancer-associated mutants.PMID 17419939Read ↗

Structural biology of the tumor suppressor p53.Semantic proximity Read ↗

p53—A Natural Cancer Killer: Structural Insights and Therapeutic ConceptsSemantic proximity Read ↗

Structure-function-rescue: the diverse nature of common p53 cancer mutants.Semantic proximity Read ↗

p53: from understanding its structure to advances in therapeutic targeting.Semantic proximity Read ↗

Drug discovery and mutant p53.Semantic proximity Read ↗

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.Semantic proximity Read ↗

Recent findings on the role of wild-type and mutant p53 in cancer development and therapySemantic proximity Read ↗

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.Semantic proximity Read ↗

[Advances on mutant p53 research].Semantic proximity Read ↗

Structural studies on mechanisms to activate mutant p53.Semantic proximity Read ↗

Targeting Oncogenic Mutant p53 for Cancer TherapySemantic proximity Read ↗

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.