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Article

Unraveling the Role of TP53 in Colorectal Cancer Therapy: From Wild-Type Regulation to Mutant.

Frontiers in bioscience (Landmark edition) - 25 Jul 2024

Li Wenshu, Li Longyuan, Yang Huan, Shi Chenxi, Lei Zhe, Guo Lingchuan, Wang Yuhong

Abstract excerpt

The p53, a pivotal tumor suppressor, regulates various cellular responses, including DNA repair and apoptosis. Normally, p53 levels are low due to murine double minute clone 2 (MDM2) mediated polyubiquitination. However, stress signals disrupt p53-MDM2 interaction, stabilizing p53 and activating target genes. Dysfunctional p53 is common in cancers, especially colorectal cancer (CRC), with TP53 mutations in 43% of...

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Antineoplastic Agents
Apoptosis
Colorectal Neoplasms
DNA Repair
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Tumor Microenvironment

Tumor Suppressor Protein p53

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Identifiers

PMID: 39082342
DOI: 10.31083/j.fbl2907272

Genes

MDM2
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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