Intermediate heterogeneity modulates coupling between chain compaction and structure formation during protein folding.

Abstract excerpt

Polypeptide chains undergo both compaction and structure formation during folding, but the extent to which these processes are mechanistically coupled remains unclear. Although initial chain collapse can precede structure formation, the two processes invariably appear coupled at later stages of folding. This raises the question of whether the fraction of molecules that undergo initial collapse, as well as the...

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