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Article

Relationship between local structural entropy and protein thermostability.

Proteins - 1 Dec 2004

Chan Chen-Hsiung, Liang Han-Kuen, Hsiao Nai-Wan, Ko Ming-Tat, Lyu Ping-Chiang, Hwang Jenn-Kang

Abstract excerpt

We developed a technique to compute structural entropy directly from protein sequences. We explored the possibility of using structural entropy to identify residues involved in thermal stabilization of various protein families. Examples include methanococcal adenylate kinase, Ribonuclease HI and holocytochrome c(551). Our results show that the positions of the largest structural entropy differences between wild...

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PMID: 15532068
DOI: 10.1002/prot.20263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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