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Article

Chemical Denaturants Smoothen Ruggedness on the Free Energy Landscape of Protein Folding.

Biochemistry - 8 Aug 2017

Malhotra Pooja, Jethva Prashant N, Udgaonkar Jayant B

Abstract excerpt

To characterize experimentally the ruggedness of the free energy landscape of protein folding is challenging, because the distributed small free energy barriers are usually dominated by one, or a few, large activation free energy barriers. This study delineates changes in the roughness of the free energy landscape by making use of the observation that a decrease in ruggedness is accompanied invariably by an...

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Identifiers

PMID: 28714672
DOI: 10.1021/acs.biochem.7b00367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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