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Article

Loops linking secondary structure elements affect the stability of the molten globule intermediate state of apomyoglobin.

FEBS letters - 1 Oct 2020

Majorina Maria A, Balobanov Vitaly A, Uversky Vladimir N, Melnik Bogdan S

Abstract excerpt

Apomyoglobin is a widely used model for studying the molecular mechanisms of globular protein folding. This work aimed to analyze the effects of rigidity and length of loops linking protein secondary structure elements on the stability of the molten globule intermediate state. For this purpose, we studied folding/unfolding of mutant apomyoglobin forms with substitutions of loop-located proline residues to glycine...

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PMID: 32770670
DOI: 10.1002/1873-3468.13905

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