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Article

The cooperativity of burst phase reactions explored.

Journal of molecular biology - 12 Nov 1999

Parker M J, Marqusee S

Abstract excerpt

The denaturant-dependence of the major, observable relaxation rates for folding (kobs) of ribonuclease HI from Escherichia coli (RNase H) and phage T4 lysozyme (T4L) reveal that, for both proteins, folding begins with the rapid and transient accumulation of intermediate species in a "burst phase" which precedes the rate-limiting formation of the native state; this is evidenced by a "rollover" in the folding limb...

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Identifiers

PMID: 10547295
DOI: 10.1006/jmbi.1999.3204

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