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Oxford Nanopore Sequencing-Based Phasing of Full-Length HLA-G Alleles Reveals Tight Allele-UTR Linkage in Chinese Kidney Transplant Recipients.

HLA - 1 Apr 2026

Chen Jianrong, Wang Rui, Zhong Bingzhou, Hu Jianmin, He Runjun, Fu Weiyi, Yao Yuan, Liao Guorong, Liu Yongguang

Abstract excerpt

HLA-G is a nonclassical class I gene with immunoregulatory functions and limited polymorphism. Its expression is strongly influenced by genetic variations in the promoter and 3' untranslated region (3'UTR). However, comprehensive data on full-length phased alleles remain poorly characterised, particularly in Asian populations. In this study, we applied long-range PCR combined with nanopore sequencing to obtain...

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PMID: 41910222
DOI: 10.1111/tan.70696

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