Article
Oxford Nanopore Sequencing-Based Phasing of Full-Length HLA-G Alleles Reveals Tight Allele-UTR Linkage in Chinese Kidney Transplant Recipients.
HLA - 1 Apr 2026
Chen Jianrong, Wang Rui, Zhong Bingzhou, Hu Jianmin, He Runjun, Fu Weiyi, Yao Yuan, Liao Guorong, Liu Yongguang
Abstract excerpt
HLA-G is a nonclassical class I gene with immunoregulatory functions and limited polymorphism. Its expression is strongly influenced by genetic variations in the promoter and 3' untranslated region (3'UTR). However, comprehensive data on full-length phased alleles remain poorly characterised, particularly in Asian populations. In this study, we applied long-range PCR combined with nanopore sequencing to obtain...
Topics
- Humans
- 3' Untranslated Regions
- Alleles
- China
- Exons
- Genetic Linkage
- HLA-G Antigens
- Introns
- Kidney Transplantation
- Nanopore Sequencing
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Transplant Recipients
- East Asian People