Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults.

Medicine and science in sports and exercise - 1 Jun 2025

Aslan Daniel H, Sayre M Katherine, Bharadwaj Pradyumna K, Ally Madeline, Maltagliati Silvio, Lai Mark H C, Wilcox Rand R, Klimentidis Yann C, Alexander Gene E, Raichlen David A

Abstract excerpt

PURPOSE: This study aimed to investigate whether self-reported walking pace (a marker of physical function) and the presence of APOE-ε4 allele interact to modify brain health outcomes. METHODS: We used data from a prospective cohort study of middle-aged to older adults from the UK Biobank who self-reported walking pace (slow or steady-to-brisk) and who were initially free of dementia ( n = 415,110). Incident...

Read the complete abstract on PubMed

Topics

Self Report
Walking Speed
Apolipoprotein E4
Alleles
Brain
Prospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Dementia

Incidence

Risk Assessment

UK Biobank

Humans

Male

Female

Adult

Middle Aged

Aged

Datasets as Topic

Organ Size

Source

Identifiers

PMID: 39780372
DOI: 10.1249/MSS.0000000000003646

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults.PMID 39780372Read ↗

APOE <sup>ε4</sup> and exercise interact to influence systemic and cerebral risk factors for dementiaSemantic proximity Read ↗

Walking to protect against cognitive decline: the role of APOE genotype and sex.Semantic proximity Read ↗

APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factorsSemantic proximity Read ↗

Interaction between <i>APOE4</i> status and lifestyle on brain and cognitive outcomes in cognitively unimpaired older adultsSemantic proximity Read ↗

The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysisSemantic proximity Read ↗

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK BiobankSemantic proximity Read ↗

Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review.Semantic proximity Read ↗

Physical activity, muscle strength, sedentary behavior, sleep, and genetic risk of stroke and dementia: findings from a large cohort study.Semantic proximity Read ↗

Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK BiobankSemantic proximity Read ↗

The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study.Semantic proximity Read ↗

Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.Semantic proximity Read ↗

An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortalitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.