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Article

Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.

Age (Dordrecht, Netherlands) - 1 Jan 2014

Alfred Tamuno, Ben-Shlomo Yoav, Cooper Rachel, Hardy Rebecca, Cooper Cyrus, Deary Ian J, Elliott Jane, Gunnell David, Harris Sarah E, Kivimaki Mika, Kumari Meena, Martin Richard M, Power Chris, Sayer Avan Aihie, Starr John M, Kuh Diana, Day Ian N M

Abstract excerpt

The APOE ε2/3/4 genotype has been associated with low-density lipoprotein cholesterol (LDL-C) and Alzheimer disease. However, evidence for associations with measures of cognitive performance in adults without dementia has been mixed, as it is for physical performance. Associations may also be evident in other genotypes implicated in LDL-C levels. As part of the Healthy Ageing across the Life Course (HALCyon)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25073452
DOI: 10.1007/s11357-014-9673-9
PMCID: PMC4150901

Genes

APOE
APOB
LDLR
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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