Article
Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
JAMA neurology - 1 Sept 2023
Walters Skylar, Contreras Alex G, Eissman Jaclyn M, Mukherjee Shubhabrata, Lee Michael L, Choi Seo-Eun, Scollard Phoebe, Trittschuh Emily H, Mez Jesse B, Bush William S, Kunkle Brian W, Naj Adam C, Peterson Amalia, Gifford Katherine A, Cuccaro Michael L, Cruchaga Carlos, Pericak-Vance Margaret A, Farrer Lindsay A, Wang Li-San, Haines Jonathan L, Jefferson Angela L, Kukull Walter A, Keene C Dirk, Saykin Andrew J, Thompson Paul M, Martin Eden R, Bennett David A, Barnes Lisa L, Schneider Julie A, Crane Paul K, Hohman Timothy J, Dumitrescu Logan
Abstract excerpt
Importance: Sex differences are established in associations between apolipoprotein E (APOE) ε4 and cognitive impairment in Alzheimer disease (AD). However, it is unclear whether sex-specific cognitive consequences of APOE are consistent across races and extend to the APOE ε2 allele. Objective: To investigate whether sex and race modify APOE ε4 and ε2 associations with cognition. Design, Setting, and Participants:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.