Article
Impact of the Apolipoprotein E ε4 Allele on the Relationship Between Healthy Lifestyle and Cognitive Decline: A Population-Based Study.
American journal of epidemiology - 1 Jul 2021
Dhana Klodian, Aggarwal Neelum T, Rajan Kumar B, Barnes Lisa L, Evans Denis A, Morris Martha C
Abstract excerpt
Adherence to a healthy lifestyle-characterized by abstaining from smoking, being physically and cognitively active, having a high-quality diet, and limiting alcohol use-is associated with slower cognitive decline in older adults, but whether this relationship extends to persons with a genetic predisposition (e.g., carriers of the ε4 allele of the apolipoprotein E gene (APOE*E4)) remains uncertain. Using data from...
Topics
- Aged
- Aging
- Alleles
- Apolipoprotein E4
- Chicago
- Cognitive Dysfunction
- Diet Surveys
- Female
- Genetic Predisposition to Disease
- Geriatric Assessment
- Healthy Lifestyle
- Humans
- Male
- Polymorphism, Single Nucleotide