Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polysomal Profiling Coupled to Allele-Specific Proteomics Reveals an EIF4H TranSNP Allele Possessing Higher mRNA Translation Potential.

Molecular & cellular proteomics : MCP - 1 Mar 2026

Hamadou Meriem Hadjer, Alunno Laura, Peroni Daniele, Pancher Michael, Mazza Fabio, Venturelli Tecla, Belli Romina, Dassi Erik, Romanel Alessandro, Inga Alberto

Abstract excerpt

To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116 colorectal adenocarcinoma-derived cells, computing allelic fractions from both total and polysome-associated RNA from RNA-Seq data. Allelic imbalance in polysomal RNA led us to nominate 52 coding variants associated with allele-specific mRNA translation, of which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Eukaryotic Initiation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HCT116 Cells

Share to Polymorphism, Single Nucleotide

Share to Polyribosomes

Share to Protein Biosynthesis

Share to Proteomics

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 41722779
DOI: 10.1016/j.mcpro.2026.101535
PMCID: PMC13010432

Genes

EIF4H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polysomal Profiling Coupled to Allele-Specific Proteomics Reveals an EIF4H TranSNP Allele Possessing Higher mRNA Translation Potential.PMID 41722779Read ↗

Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potentialSemantic proximity Read ↗

Allele-resolved monosome and polysome sequencing identifies functional cis-acting variants affecting mRNA translation efficiencySemantic proximity Read ↗

Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms.Semantic proximity Read ↗

Alternate RNA decoding results in stable and abundant proteins in mammalsSemantic proximity Read ↗

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and diseaseSemantic proximity Read ↗

TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types <i>in vivo</i>Semantic proximity Read ↗

Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans.Semantic proximity Read ↗

Integrative analysis of RNA, translation and protein levels reveals distinct regulatory variation across humansSemantic proximity Read ↗

Genome-wide search for exonic variants affecting translational efficiency.Semantic proximity Read ↗

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read ↗

Third-nucleotide codon bias and synonymous codon bias define functional translational programs that shape human tissue and cancer proteomesSemantic proximity Read ↗

Ultra-parallel ribosome profiling platform with RNA-dependent RNA amplificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.