Article

Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential

2025-04-23

Abstract excerpt

To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to nominate 52 coding variants associated with allele-specific mRNA translation, of which 16 are nonsynonymous. To valid...

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Literature Corpus work: aba87216-5b88-5224-bb5c-0e6bb4c050cb
DOI: 10.1101/2025.04.17.649328

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Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potentialDOI 10.1101/2025.04.17.649328Read

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