Article
Genome-wide search for exonic variants affecting translational efficiency.
Nature communications - 1 Jan 2013
Li Quan, Makri Angeliki, Lu Yang, Marchand Luc, Grabs Rosemarie, Rousseau Marylene, Ounissi-Benkalha Houria, Pelletier Jerry, Robert Francis, Harmsen Eef, Hudson Thomas J, Pastinen Tomi, Polychronakos Constantin, Qu Hui-Qi
Abstract excerpt
The search for expression quantitative trait loci has traditionally centred entirely on the process of transcription, whereas variants with effects on messenger RNA translation have not been systematically studied. Here we present a high-throughput approach for measuring translational cis-regulation in the human genome. Using ribosomal association as proxy for translational efficiency of polymorphic messenger...
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