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Article

PIK3CA mutation-induced immune microenvironment remodeling sensitizes cervical cancer to immunotherapy.

Frontiers in immunology - 1 Jan 2026

Zhu Fei, Xie Xingyun, Wang Cong, Liu Jin, Chen Ying, Hu Dan, Xu Qin

Abstract excerpt

PIK3CA is one of the most frequently mutated genes in cervical cancer (CC). However, its clinical utility is hampered by paradoxical treatment-dependent outcomes, restricting its application in precision oncology. To address this issue, we constructed a high-resolution single-cell transcriptomic atlas of the CC tumor microenvironment. It was found that PIK3CA mutations induce a dichotomous TME, simultaneously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41958669
DOI: 10.3389/fimmu.2026.1780752
PMCID: PMC13057328

Genes

PIK3CA
ANGPTL4
CD44
MMP9
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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