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Article

Single-cell spatial analysis stratifies lung adenocarcinoma with rare actionable mutations and reveals immune-modulatory cellular crosstalk.

Cell reports. Medicine - 19 May 2026

Ma Jianli, Li Xin, Qian Niansong, Li Shujin, Li Lijun, Zhang Xiaoxin, Su Liqian, Yang Yue, Luo Haitao, Yin Mingzhu, Zhang Minghui

Abstract excerpt

Lung adenocarcinoma (LUAD) harboring distinct actionable oncogenic mutations exhibits differential responses to immune checkpoint inhibitors (ICI); however, the underlying mechanisms remain elusive. Here, we report comprehensive single-cell spatial atlases of tumors from 38 LUAD patients, predominantly harboring rare actionable oncogenes. Stratifying patients by consensus meta-programs (MP) reveals ICI-MP-H...

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Share to Adenocarcinoma of Lung
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 42013848
DOI: 10.1016/j.xcrm.2026.102760
PMCID: PMC13198233

Genes

IFI6
APP
CD74

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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