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Safeguarding VSMC Contractile Phenotype With In Situ circRNA-mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis.

Advanced materials (Deerfield Beach, Fla.) - 1 Mar 2026

Hu Shunqi, Ling Shifeng, Liang Fubang, Pan Yanjun, Wang Juan, Bao Wenjie, Zhu Jiameng, Wang Fan, Du Yawei, Cui Wenguo, Yin Meng

Abstract excerpt

Small-diameter vascular grafts (SDVGs) often fail due to restenosis driven by endothelial cell (EC)-derived PDGF-BB, which shifts vascular smooth muscle cells (VSMCs) toward a synthetic phenotype. Despite mechanistic insights, durable, localized, and cell-specific control of this crosstalk remains elusive. Here, we developed a circRNA-based in situ antibody engineering strategy to functionalize SDVGs,...

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Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Constriction, Pathologic

Share to Endothelial Cells

Share to Human Umbilical Vein Endothelial Cells

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Identifiers

PMID: 41721546
DOI: 10.1002/adma.202522615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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