Modulation of Smooth Muscle Cell Phenotype for Translation of Tissue-Engineered Vascular Grafts.

Abstract excerpt

Translation of small-diameter tissue-engineered vascular grafts (TEVGs) for the treatment of coronary artery disease (CAD) remains an unfulfilled promise. This is largely due to the limited integration of TEVGs into the native vascular wall-a process hampered by the insufficient smooth muscle cell (SMC) infiltration and extracellular matrix deposition, and low vasoactivity. These processes can be promoted through...

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• Cell Differentiation
• Cells, Cultured
• Electrospun Nanofibers in Biomedical Applications
• Muscle, Smooth, Vascular
• Myocytes, Smooth Muscle