Article

Degradable Scaffold-Mediated Synergistic Matrix Formation by Endogenous Cells: An In Vivo Manufacturing Strategy for Off-the-Shelf Cardiovascular Bypass Grafts to Address Clinical Shortages

2025-10-01

Abstract excerpt

<title>Abstract</title> Cardiovascular bypass surgery is an important treatment for severe atherosclerosis, but the scarcity of autologous blood vessels restricts its clinical application. Although tissue-engineered vascular grafts (TEVGs) have potential, the long cycle of traditional in vitro culture makes it difficult to achieve "off-the-shelf" supply. This study innovatively proposes a strategy of guiding...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed3bb15e-0b40-51a7-9533-9c4e4787ff06
DOI: 10.21203/rs.3.rs-7515189/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Degradable Scaffold-Mediated Synergistic Matrix Formation by Endogenous Cells: An In Vivo Manufacturing Strategy for Off-the-Shelf Cardiovascular Bypass Grafts to Address Clinical ShortagesDOI 10.21203/rs.3.rs-7515189/v1Read

Scaffold and Cell-Based Tissue Engineering Approaches as Alternative Therapy for Blood Vessel DiseaseSemantic proximity Read

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channelsSemantic proximity Read

Patient-as-bioreactor in-body tissue architecture generates autologous multicellular constructs for durable diabetic wound repairSemantic proximity Read

Modular biofabrication of a vascularized skeletal muscle model through endothelialized microvascular seedsSemantic proximity Read

hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle LossSemantic proximity Read

Engineering a Matrix-Preserving Vascular dECM Platform with Tunable Stiffness for In Vitro Vascular RemodelingSemantic proximity Read

Towards 3D-Bioprinting of an Endocrine Pancreas: A Building-Block Concept for Bioartificial Insulin-Secreting TissueSemantic proximity Read

Composition of intraperitoneally implanted electrospun conduits modulates cellular elastic matrix generation.Semantic proximity Read

A Sacrificial 3D Printed Vessel-on-Chip Demonstrates a Versatile Approach to Model Connective Tissue PathologySemantic proximity Read

Immunomodulatory Porous Regenerative Scaffolds for in situ Vascular EngineeringSemantic proximity Read

A novel method for generating 3D constructs with branched vascular networks using multi-materials bioprinting and direct surgical anastomosisSemantic proximity Read

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing PotentialSemantic proximity Read