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Article

Aligned core-sheath structured fibers prevent intimal hyperplasia via modulate macrophage polarization and smooth muscle cell phenotype in vascular regeneration.

Journal of nanobiotechnology - 27 May 2026

Li Yunhuan, Liu Yutong, Zhang Kuihua, Jiang Nan, Hou Keqing, Chen Liyu, Lin Fan, Yan Zhiyong, Zhai Changlin, Zhu Tonghe, Yin Anlin

Abstract excerpt

Small-diameter vascular grafts face limited success due to thrombosis, intimal hyperplasia, and insufficient remodeling. Here, we developed a tubular graft composed of aligned core-sheath structured PLCL fibers with sodium tanshinone IIA sulfonate (STS)-loaded polyethylene oxide (PEO) cores. The graft exhibited uniform structures, appropriate porosity, and matched mechanical properties. In vitro, aligned fibers...

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Source

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Identifiers

PMID: 42204588
DOI: 10.1186/s12951-026-04606-9
PMCID: PMC13404877

Genes

STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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