Article
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Biochimica et biophysica acta. Molecular basis of disease - 1 Dec 2023
Zhang Qing, Du Gaohui, Tong Lu, Guo Xiaopeng, Wei Yumiao
Abstract excerpt
Neoatherosclerosis (NA), the main pathological basis of late stent failure, is the main limitation of interventional therapy. However, the specific pathogenesis and treatment remain unclear. In vivo, NA model was established by carotid wire injury and high-fat feeding in ApoE-/- mice. Oxidized low-density lipoprotein receptor-1/lectin-like oxidized low-density lipoprotein receptor-1 (OLR1/LOX-1), a specific...
Topics
- Animals
- Mice
- Arachidonate 15-Lipoxygenase
- Hepatocytes
- Lipoproteins, LDL
- Muscle, Smooth, Vascular
- Phenotype
- Proprotein Convertase 9
- Scavenger Receptors, Class E