Article

Nanocarrier-driven dual targeting VCAM-1/Collagen IV enables RNA interference-mediated silencing of Smad3 and Runx2 to mitigate aortic valve disease

2025-08-02

Abstract excerpt

<h4>BACKGROUND</h4> Calcific aortic valve disease (CAVD) is a common malady with few treatment options other than valve replacement by surgery or transcatheter aortic valve implantation (TAVI). Endothelial-to-mesenchymal transition (EndMT) of valvular endothelial cells and osteogenic differentiation of valvular interstitial cells are crucial processes of CAVD. Smad3 and Runx2 are key transcription factors (TFs) t...

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Literature Corpus work: 4c1e088e-6a86-51d7-a57d-a891c329eeae
DOI: 10.1101/2025.07.31.668019

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