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Article

Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms.

Nature genetics - 1 Jun 2022

Grishin Dennis, Gusev Alexander

Abstract excerpt

While many germline cancer risk variants have been identified through genome-wide association studies (GWAS), the mechanisms by which these variants operate remain largely unknown. Here we used 406 cancer ATAC-Seq samples across 23 cancer types to identify 7,262 germline allele-specific accessibility QTLs (as-aQTLs). Cancer as-aQTLs had stronger enrichment for cancer risk heritability (up to 145 fold) than any...

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Identifiers

PMID: 35697866
DOI: 10.1038/s41588-022-01075-2
PMCID: PMC9886437

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