Article

Multi-tissue analyses of allele-specific chromatin accessibility nominate likely functional variants for type 2 diabetes

2026-07-15

Abstract excerpt

Genome-wide association studies (GWAS) have identified >1,200 signals associated with type 2 diabetes (T2D), yet identifying functional variants remains challenging because the majority of them lie in noncoding regions of the genome and are in areas of high linkage disequilibrium (LD). While chromatin accessibility QTL (caQTL) and expression QTL (eQTL) analyses are useful for nominating regulatory mechanisms under...

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Literature Corpus work: b2aa04a3-8b3e-506e-8fff-883807c4cf62
DOI: 10.64898/2026.07.14.26358094

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