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Article

Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.

Molecules and cells - 1 Aug 2014

Kim Yonghwan

Abstract excerpt

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of...

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Share to DNA Damage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24938228
DOI: 10.14348/molcells.2014.0118
PMCID: PMC4145367

Genes

SLX4

Provenance

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