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Article

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.

Nature communications - 15 Jul 2020

Berti Matteo, Teloni Federico, Mijic Sofija, Ursich Sebastian, Fuchs Jevgenij, Palumbieri Maria Dilia, Krietsch Jana, Schmid Jonas A, Garcin Edwige B, Gon Stéphanie, Modesti Mauro, Altmeyer Matthias, Lopes Massimo

Abstract excerpt

Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, HR-mediated fork remodeling promotes cancer chemoresistance, by as-yet elusive mechanisms. Five HR cofactors - the RAD51 paralogs RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 - recently emerged as crucial tumor suppressors. Albeit extensively characterized in DNA repair,...

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Identifiers

PMID: 32669601
DOI: 10.1038/s41467-020-17324-z
PMCID: PMC7363682

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