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Article

Mitochondrial heteroplasmy is a risk factor for the development of chronic lymphocytic leukemia.

Nature communications - 18 Feb 2026

Pasca Sergiu, Hong Yun Soo, Shi Wen, Puiu Daniela, Lake Nicole J, Lek Monkol, Guallar Eliseo, Arking Dan E, Gondek Lukasz P

Abstract excerpt

Chronic lymphocytic leukemia (CLL) can arise from lymphoid clonal hematopoiesis of indeterminate potential (L-CHIP), but many individuals who develop CLL lack detectable L-CHIP prior to diagnosis. To identify additional predictors of CLL risk, we analyze mitochondrial heteroplasmy in 419,154 individuals from the UK Biobank (UKB). Heteroplasmy is associated with a 1.5-fold increased risk of developing CLL, and...

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Identifiers

PMID: 41708630
DOI: 10.1038/s41467-026-69861-8
PMCID: PMC13031533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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