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Detection and Characterization of Clonal Hematopoiesis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Locher Benjamin N, Löwe Pelle, Christen Friederike, Damm Frederik

Abstract excerpt

Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones resulting from the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs). It is linked to adverse systemic effects, including hematologic malignancies, cardiovascular diseases, metabolic disorders, as well as liver and kidney ailments, ultimately contributing to elevated overall mortality.Given its...

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PMID: 39424737
DOI: 10.1007/978-1-0716-4188-0_20

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