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Article

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms.

Nature communications - 22 Nov 2024

Hong Yun Soo, Pasca Sergiu, Shi Wen, Puiu Daniela, Lake Nicole J, Lek Monkol, Ru Meng, Grove Megan L, Prizment Anna, Joshu Corinne E, Platz Elizabeth A, Guallar Eliseo, Arking Dan E, Gondek Lukasz P

Abstract excerpt

Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological malignancies. We explore how these two markers relate and influence myeloid neoplasms incidence, and their role in risk stratification. We find that heteroplasmy is...

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Identifiers

PMID: 39578475
DOI: 10.1038/s41467-024-54443-3
PMCID: PMC11584845

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