Article
Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification.
Cancer research - 15 Jul 2025
Hubbard Aubrey K, Brown Derek W, Liu Jie, Chan Irenaeus C, Zhou Weiyin, Genovese Giulio, DePaulis Alexander, Srinivasan Sruthi, Lin Shu-Hong, Blechter Batel, Buller Ian D, Zeng Qinglin, Cao Yin, Huang Wen-Yi, Freedman Neal D, Zhang Haoyu, Dutta Diptavo, Chanock Stephen J, Bolton Kelly L, Machiela Mitchell J
Abstract excerpt
Both acquired mutations and germline genetic variation are known risk factors for chronic lymphocytic leukemia (CLL). The joint characterization of germline, acquired, and clinical risk has the potential to improve CLL risk prediction. In this study, we investigated whether the inclusion of a CLL-associated polygenic score (PGS) and two common types of clonal hematopoiesis (CH), autosomal mosaic chromosomal...
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