Article

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

2024-04-08

Abstract excerpt

The most well-known pathogenic risk factor for myeloid neoplasms (MN) is clonal hematopoiesis of indeterminate potential (CHIP) 1 . However, MN can develop in CHIP negative individuals, indicating that additional markers of clonal expansion might also be informative. Heteroplasmy, defined as the presence of mitochondrial DNA (mtDNA) mutations in a subset of cellular mtDNA, has been associated with hematological ma...

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Literature Corpus work: 7b95ef28-c092-5570-828d-eda57fa98e7f
DOI: 10.1101/2024.04.07.24305454

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